Research Paper Volume 13, Issue 2 pp 2365—2378

The mutational pattern of homologous recombination-related (HRR) genes in Chinese colon cancer and its relevance to immunotherapy responses

Associations among mutations in HRR genes, TMB and the MSI status. (A–C) Bar plots showing the percentage of TMB-high patients in the HRR-mut group compared with the HRR-wt group in the Chinese (A) and TCGA (C) cohorts. (B–D) Bar plots showing the percentage of MSI-H patients in the HRR-mut group compared with the HRR-wt group in the Chinese (B) and TCGA (D) cohorts. Comparisons between the groups were performed with Fisher’s exact test (* P P P P > 0.05). (E, F) Venn diagrams illustrating the overlap between patients with HRR-mut, TMB-H, and MSI-H COAD in the Chinese (E) and TCGA (F) cohorts.

Figure 2. Associations among mutations in HRR genes, TMB and the MSI status. (AC) Bar plots showing the percentage of TMB-high patients in the HRR-mut group compared with the HRR-wt group in the Chinese (A) and TCGA (C) cohorts. (BD) Bar plots showing the percentage of MSI-H patients in the HRR-mut group compared with the HRR-wt group in the Chinese (B) and TCGA (D) cohorts. Comparisons between the groups were performed with Fisher’s exact test (* P < 0.05; ** P < 0.01; *** P < 0.001; ns, P > 0.05). (E, F) Venn diagrams illustrating the overlap between patients with HRR-mut, TMB-H, and MSI-H COAD in the Chinese (E) and TCGA (F) cohorts.