Research Paper Volume 13, Issue 2 pp 2727—2749

Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation

Effects of melatonin on the quality of matured oocytes from OBZ-exposed mice in vivo. (A) Representative images of ROS and GSH levels in the control, OBZ-exposed, and melatonin+OBZ-treated oocytes. Scale bar, 50 μm. (B) Intracellular ROS and (C) GSH levels in mouse oocytes from each treatment group. (D) Proportion of early apoptotic oocytes in each treatment group. (E) Proportion of oocytes with aberrant distribution of mitochondria in each treatment group. (F) Relative MMP is represented as the ratio of red to green intensity. Values indicated by different letters are significantly different (P

Figure 9. Effects of melatonin on the quality of matured oocytes from OBZ-exposed mice in vivo. (A) Representative images of ROS and GSH levels in the control, OBZ-exposed, and melatonin+OBZ-treated oocytes. Scale bar, 50 μm. (B) Intracellular ROS and (C) GSH levels in mouse oocytes from each treatment group. (D) Proportion of early apoptotic oocytes in each treatment group. (E) Proportion of oocytes with aberrant distribution of mitochondria in each treatment group. (F) Relative MMP is represented as the ratio of red to green intensity. Values indicated by different letters are significantly different (P < 0.05). The experiments were repeated three times, with n = 15-20 per group. Control, untreated control group; OBZ, oxybenzone-exposed group; OBZ+MT, “oxybenzone + melatonin” treatment group.