Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

The expression of eIF2α and peIF2α in aged ALDH2 overexpression mice and aged Alda1-treated mice. (A) A typical WB image of eIF2α and peIF2α in aged ALDH2 overexpression mice; (B) The expression of peIF2α/eIF2α in aged ALDH2 overexpression mice; (C) a typical WB image of eIF2α and peIF2α in aged Alda1-treated mice; (D) The expression of peIF2α/eIF2α in aged Alda1-treated mice. All analyses were performed in duplicate. Values are presented as the mean ± SD, n = 4 mice per group. **Pvs young (WT) group or aged (DMSO) group and aged (Alda1) group vs Young group; ##Pvs aged (WT) group or aged (Alda1) group vs aged (DMSO) group.

Figure 10. The expression of eIF2α and peIF2α in aged ALDH2 overexpression mice and aged Alda1-treated mice. (A) A typical WB image of eIF2α and peIF2α in aged ALDH2 overexpression mice; (B) The expression of peIF2α/eIF2α in aged ALDH2 overexpression mice; (C) a typical WB image of eIF2α and peIF2α in aged Alda1-treated mice; (D) The expression of peIF2α/eIF2α in aged Alda1-treated mice. All analyses were performed in duplicate. Values are presented as the mean ± SD, n = 4 mice per group. **P<0.01: aged (WT) group and aged (ALDH2+) group vs young (WT) group or aged (DMSO) group and aged (Alda1) group vs Young group; ##P<0.01: aged (ALDH2+) group vs aged (WT) group or aged (Alda1) group vs aged (DMSO) group.