Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

ALDH2 enhanced aged mouse retinal function. (A, B) A typical dark-adaptation 3.0 response image and amplification of the dark-adaptation 3.0 response b wave in ALDH2 overexpression mice; (C, D) A typical dark-adaptation 3.0 response image and the amplification of the dark-adaptation 3.0 response b wave in Alda1-treated mice. All analyses were performed in duplicate. Values are presented as the mean ± SD, n = 10 mice per group. *Pvs young (WT) group or aged (DMSO) group and aged (Alda1) group vs young group; #Pvs aged (WT) group or aged (Alda1) group vs aged (DMSO) group.

Figure 3. ALDH2 enhanced aged mouse retinal function. (A, B) A typical dark-adaptation 3.0 response image and amplification of the dark-adaptation 3.0 response b wave in ALDH2 overexpression mice; (C, D) A typical dark-adaptation 3.0 response image and the amplification of the dark-adaptation 3.0 response b wave in Alda1-treated mice. All analyses were performed in duplicate. Values are presented as the mean ± SD, n = 10 mice per group. *P<0.05: aged (WT) group and aged (ALDH2+) group vs young (WT) group or aged (DMSO) group and aged (Alda1) group vs young group; #P<0.05: aged (ALDH2+) group vs aged (WT) group or aged (Alda1) group vs aged (DMSO) group.