Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

The expression of GRP78 in ALDH2+ overexpression mice during the normal aging process. (A, B) A typical WB image of GRP78 and the confirmation of GRP78 expression by WB; (C, D) A typical immunofluorescence image of GRP78 and the confirmation of GRP78 expression by immunofluorescence. All analyses were performed in duplicate. Scale bar: 50 μm. Values are presented as the mean ± SD, n = 4 mice per group. *Pvs young (WT); #Pvs aged (WT).

Figure 8. The expression of GRP78 in ALDH2+ overexpression mice during the normal aging process. (A, B) A typical WB image of GRP78 and the confirmation of GRP78 expression by WB; (C, D) A typical immunofluorescence image of GRP78 and the confirmation of GRP78 expression by immunofluorescence. All analyses were performed in duplicate. Scale bar: 50 μm. Values are presented as the mean ± SD, n = 4 mice per group. *P<0.05: aged (WT) and aged (ALDH2+) vs young (WT); #P<0.05: aged (ALDH2+) vs aged (WT).