Research Paper Volume 13, Issue 2 pp 2864—2884

The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis

Silencing LHPP or GAS5 promotes cisplatin-resistant NSCLC cell migration and invasion. (A, C) Transwell invasion assays were used to measure the invasion of H1299/DDP cells transfected with si-NC, si-LHPP, si-GAS5 or si-GAS5 + pPG-anti-miR-217. (B, D) Wound healing assays were used to measure the migration of H1299/DDP cells transfected with si-NC, si-LHPP, si-GAS5 or si-GAS5 + pPG-anti-miR-217. *p

Figure 6. Silencing LHPP or GAS5 promotes cisplatin-resistant NSCLC cell migration and invasion. (A, C) Transwell invasion assays were used to measure the invasion of H1299/DDP cells transfected with si-NC, si-LHPP, si-GAS5 or si-GAS5 + pPG-anti-miR-217. (B, D) Wound healing assays were used to measure the migration of H1299/DDP cells transfected with si-NC, si-LHPP, si-GAS5 or si-GAS5 + pPG-anti-miR-217. *p < 0.05, **p < 0.01, ***p < 0.001. This experiment was repeated at least three times.