Research Paper Volume 13, Issue 3 pp 3898—3908

Intranasal treatment of lixisenatide attenuated emotional and olfactory symptoms via CREB-mediated adult neurogenesis in mouse depression model

LXT intranasal treatment enhanced adult neurogenesis in hippocampus and olfactory bulbs. (A, D) Confocal image to show the distribution and cell number of DCX+ immature neurons (Red) and BrdU+ (Green) newborn cells in olfactory bulb and hippocampal DG region. (B, C) DCX+ immature neuron cell density and the newborn DCX+/BrdU+ cell density in olfactory bulb was recovered by LXT treatment. (E, F) DCX+ immature neuron cell density and the newborn DCX+/BrdU+ cell density in hippocampal DG region was recovered by LXT treatment.

Figure 2. LXT intranasal treatment enhanced adult neurogenesis in hippocampus and olfactory bulbs. (A, D) Confocal image to show the distribution and cell number of DCX+ immature neurons (Red) and BrdU+ (Green) newborn cells in olfactory bulb and hippocampal DG region. (B, C) DCX+ immature neuron cell density and the newborn DCX+/BrdU+ cell density in olfactory bulb was recovered by LXT treatment. (E, F) DCX+ immature neuron cell density and the newborn DCX+/BrdU+ cell density in hippocampal DG region was recovered by LXT treatment.