Research Paper Volume 13, Issue 4 pp 5069—5086

Inhibiting Th1/2 cells influences hepatic capillarization by adjusting sinusoidal endothelial fenestrae through Rho-ROCK-myosin pathway

Morphological change in each group in the in vivo experiments. (A) Collagen fiber distribution in each group. (B) CD34 expression in each group (the black head of arrow indicates CD34). (C) Changes of fenestrae in each group (the yellow head of arrow indicates fenestrae on the LSECs). (D) Changes in the basement membrane between the experimental groups and the control groups (the red circle in the NC group indicated the fenestrae on LSECs, and red arrow in other groups showed the basement membrane). (E) Liver fibrosis score of each group in (A). (F) Quantification of CD34 expression of each group in (B). (G) Quantification of fenestrae number of each group in (C). *p

Figure 3. Morphological change in each group in the in vivo experiments. (A) Collagen fiber distribution in each group. (B) CD34 expression in each group (the black head of arrow indicates CD34). (C) Changes of fenestrae in each group (the yellow head of arrow indicates fenestrae on the LSECs). (D) Changes in the basement membrane between the experimental groups and the control groups (the red circle in the NC group indicated the fenestrae on LSECs, and red arrow in other groups showed the basement membrane). (E) Liver fibrosis score of each group in (A). (F) Quantification of CD34 expression of each group in (B). (G) Quantification of fenestrae number of each group in (C). *p < 0.05, **p < 0.01, ***p < 0.001.