Research Paper Volume 13, Issue 2 pp 3031—3044

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

Schematic diagram of treatment schedule and protocol design. Rats received 100 μg/kg, 200 μg/kg and 300 μg/kg TPL (iv) 20 min before CPB/DHCA and then daily (iv) up to day 7 post operation. On day 3 post operation, rats underwent elevated plus-maze test and Y maze test. From day 3 through day 7 post operation, rats underwent Morris water maze test. After Morris water maze test on day 7 post operation, rats were euthanized and collected plasma and brain tissues to prepare further assessments.

Figure 8. Schematic diagram of treatment schedule and protocol design. Rats received 100 μg/kg, 200 μg/kg and 300 μg/kg TPL (iv) 20 min before CPB/DHCA and then daily (iv) up to day 7 post operation. On day 3 post operation, rats underwent elevated plus-maze test and Y maze test. From day 3 through day 7 post operation, rats underwent Morris water maze test. After Morris water maze test on day 7 post operation, rats were euthanized and collected plasma and brain tissues to prepare further assessments.