Research Paper Volume 13, Issue 2 pp 3045—3059

Transplantation of bone marrow-derived mesenchymal stem cells with silencing of microRNA-138 relieves pelvic organ prolapse through the FBLN5/IL-1β/elastin pathway

miR-138 promoted the expression of IL-1β by targeting FBLN5, and the up-regulation of IL-1β expression inhibited the expression of elastin and promoted POP progression. After silencing miR-138 in BMSCs and transplant, the POP in PFD rats was alleviated.

Figure 6. miR-138 promoted the expression of IL-1β by targeting FBLN5, and the up-regulation of IL-1β expression inhibited the expression of elastin and promoted POP progression. After silencing miR-138 in BMSCs and transplant, the POP in PFD rats was alleviated.