Research Paper Volume 13, Issue 4 pp 5674—5685

High expression of heme oxygenase-1 in tumor-associated macrophages characterizes a poor-prognosis subtype in nasopharyngeal carcinoma

High expression of HO-1 is associated with worse prognosis of nasopharyngeal carcinoma. Survival was estimated by the Kaplan-Meier method and compared with log-rank tests. (A) The HO-1 high group exhibited significantly lower overall survival than the HO-1 low group (log-rank p-value = 0.005). (B) The HO-1 high group exhibited significantly lower progression-free survival than the HO-1 low group (log-rank p-value = 0.009). (C) The HO-1 high group exhibited significantly lower local-regional failure-free survival than the HO-1 low group (log-rank p-value = 0.048). (D) The HO-1 high group exhibited lower distant metastasis-free survival than the HO-1 low group, but the difference is not statistically significant (log-rank p-value = 0.448).

Figure 3. High expression of HO-1 is associated with worse prognosis of nasopharyngeal carcinoma. Survival was estimated by the Kaplan-Meier method and compared with log-rank tests. (A) The HO-1 high group exhibited significantly lower overall survival than the HO-1 low group (log-rank p-value = 0.005). (B) The HO-1 high group exhibited significantly lower progression-free survival than the HO-1 low group (log-rank p-value = 0.009). (C) The HO-1 high group exhibited significantly lower local-regional failure-free survival than the HO-1 low group (log-rank p-value = 0.048). (D) The HO-1 high group exhibited lower distant metastasis-free survival than the HO-1 low group, but the difference is not statistically significant (log-rank p-value = 0.448).