Research Paper Volume 13, Issue 4 pp 5674—5685

High expression of heme oxygenase-1 in tumor-associated macrophages characterizes a poor-prognosis subtype in nasopharyngeal carcinoma

Schematic diagram of HO-1 regulating CD163 expression and tumor-associated macrophage (TAM) polarization in the progression of nasopharyngeal carcinoma. The overexpression of HO-1 could promote CD163 expression, and drive TAM polarization toward M2 phenotype. Finally, M2 TAMs related immune escape promotes the progression of nasopharyngeal carcinoma.

Figure 6. Schematic diagram of HO-1 regulating CD163 expression and tumor-associated macrophage (TAM) polarization in the progression of nasopharyngeal carcinoma. The overexpression of HO-1 could promote CD163 expression, and drive TAM polarization toward M2 phenotype. Finally, M2 TAMs related immune escape promotes the progression of nasopharyngeal carcinoma.