Research Paper Volume 13, Issue 2 pp 3101—3111

Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway

Sleep deprivation aggravates brain damage after SAH. (A) Brain water content assay shows that sleep deprivation aggravated brain edema after SAH. (B, C) TUNEL staining (B) and quantification (C) show that sleep deprivation increased apoptosis after SAH. Scale bar, 50 μm. (D) Western blot shows that sleep deprivation increased expression of cleaved-caspase-3 (C-caspase-3) after SAH. The data was represented as means ± SEM. #p *p

Figure 1. Sleep deprivation aggravates brain damage after SAH. (A) Brain water content assay shows that sleep deprivation aggravated brain edema after SAH. (B, C) TUNEL staining (B) and quantification (C) show that sleep deprivation increased apoptosis after SAH. Scale bar, 50 μm. (D) Western blot shows that sleep deprivation increased expression of cleaved-caspase-3 (C-caspase-3) after SAH. The data was represented as means ± SEM. #p < 0.05 vs. Sham group and *p < 0.05 vs. SAH group.