Research Paper Volume 13, Issue 4 pp 5875—5891

Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression

Deletion of the IDO1 retrieves hippocampal BOLD signal in mice under CUMS treatment. (A) Sketch of the hippocampus. (B, C) Images of coronal, axial and sagittal planes show the changes of BOLD–fMRI signal in the hippocampal region between different groups according to the fALFF analysis. The voxel-level height threshold was p  (uncorrected) and the cluster-extent threshold was 20 voxels.

Figure 5. Deletion of the IDO1 retrieves hippocampal BOLD signal in mice under CUMS treatment. (A) Sketch of the hippocampus. (B, C) Images of coronal, axial and sagittal planes show the changes of BOLD–fMRI signal in the hippocampal region between different groups according to the fALFF analysis. The voxel-level height threshold was p < 0.005 (uncorrected) and the cluster-extent threshold was 20 voxels.