Research Paper Volume 13, Issue 2 pp 1649—1670

Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling

Sulforaphane mediates longevity via DAF-2/DAF-16 signaling. (A) Kaplan-Meier survival curves were generated by the use of C. elegans strains with mutations in daf-2/daf-16, daf-18, age-1, akt-1 and akt-2, and the P values, indicating significance or not, are given within the diagrams. (B, C) Schematic representation of DAF-2/DAF-16 signaling under physiological conditions and after treatment with sulforaphane, as described in detail in the results section.

Figure 7. Sulforaphane mediates longevity via DAF-2/DAF-16 signaling. (A) Kaplan-Meier survival curves were generated by the use of C. elegans strains with mutations in daf-2/daf-16, daf-18, age-1, akt-1 and akt-2, and the P values, indicating significance or not, are given within the diagrams. (B, C) Schematic representation of DAF-2/DAF-16 signaling under physiological conditions and after treatment with sulforaphane, as described in detail in the results section.