Research Paper Volume 13, Issue 5 pp 6724—6739

MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein

Skp2 overexpression abrogates miR-506-mediated cell viability inhibition and apoptosis induction. (A) Viability was detected by MTT in osteosarcoma cells after miR-506 overexpression and Skp2 upregulation. *p #PB) Apoptosis was examined by flow cytometry in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. (C) Quantification of apoptosis results.

Figure 4. Skp2 overexpression abrogates miR-506-mediated cell viability inhibition and apoptosis induction. (A) Viability was detected by MTT in osteosarcoma cells after miR-506 overexpression and Skp2 upregulation. *p < 0.05 vs control, #P<0.05 vs miR-506 mimics or Skp2 cDNA transfection. (B) Apoptosis was examined by flow cytometry in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. (C) Quantification of apoptosis results.