Research Paper Volume 13, Issue 5 pp 6724—6739

MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein

Skp2 overexpression rescues miR-506-induced inhibition of motility. (A) Left: Wound healing assay was done in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. Right: Quantitative results of migration. *p #PB) Left: Invasion was examined by Transwell assay in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. Right: Quantitative results of invasion.

Figure 5. Skp2 overexpression rescues miR-506-induced inhibition of motility. (A) Left: Wound healing assay was done in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. Right: Quantitative results of migration. *p < 0.05 vs control, #P<0.05 vs miR-506 mimics or Skp2 cDNA transfection. (B) Left: Invasion was examined by Transwell assay in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. Right: Quantitative results of invasion.