Research Paper Volume 13, Issue 5 pp 6724—6739

MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein

Skp2 overexpression attenuates miR-506-induced upregulation of FOXO1 and p57. (A) Western blotting detection of the protein level of Skp2 and its targets in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. (B) Quantitative results of (A). *p #p

Figure 6. Skp2 overexpression attenuates miR-506-induced upregulation of FOXO1 and p57. (A) Western blotting detection of the protein level of Skp2 and its targets in osteosarcoma cells after miR-506 mimic transfection and Skp2 upregulation. (B) Quantitative results of (A). *p < 0.05 vs control, #p < 0.05 vs miR-506 mimics or Skp2 cDNA transfection.