Research Paper Volume 13, Issue 5 pp 6724—6739
MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein
Figure 8. Skp2 downregulation enhances miR-506-induced inhibition of motility. (A) Left: Wound healing assay was conducted in osteosarcoma cells after miR-506 mimic transfection and Skp2 downregulation. Right: Quantitative results of migration. *p < 0.05 vs control, #P<0.05 vs miR-506 mimics or Skp2 siRNA transfection. (B) Left: Invasion ability was examined by Transwell assay in osteosarcoma cells after miR-506 mimic transfection and Skp2 downregulation. Right: Quantitative results of invasion.