Research Paper Volume 13, Issue 5 pp 7382—7396

Integrative analysis of exosomal microRNA-149-5p in lung adenocarcinoma

Exosomal miR-149-5p regulated the proliferation and apoptotic rates of tumor cells by targeting AMOTL2. (A) The binding site of miR-149-5p and AMOTL2. (B) Dual luciferase reporter gene assay of exosomal miR-149-5p and AMOTL2. (C) The AMOTL2 protein expression in cells transfected with miR-149-5p mimic and mimic NC. (D) The AMOTL2 mRNA expression in cells transfected with miR-149-5p mimic and mimic NC. (E) GSEA results of AMOTL2 in TCGA-LUAD cohort. (F) Univariate and multivariate analyses of AMOTL2 in TCGA-LUAD cohort. (G) ROC curve analysis of AMOTL2 in TCGA-LUAD cohort. ***p

Figure 8. Exosomal miR-149-5p regulated the proliferation and apoptotic rates of tumor cells by targeting AMOTL2. (A) The binding site of miR-149-5p and AMOTL2. (B) Dual luciferase reporter gene assay of exosomal miR-149-5p and AMOTL2. (C) The AMOTL2 protein expression in cells transfected with miR-149-5p mimic and mimic NC. (D) The AMOTL2 mRNA expression in cells transfected with miR-149-5p mimic and mimic NC. (E) GSEA results of AMOTL2 in TCGA-LUAD cohort. (F) Univariate and multivariate analyses of AMOTL2 in TCGA-LUAD cohort. (G) ROC curve analysis of AMOTL2 in TCGA-LUAD cohort. ***p<0.001 (WT: wild type; MUT: mutant type).