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Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease

Exosome-lncRNA ZFAS1 promoted fibrosis in ex-vivo. (A) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (B) The represented image of immunofluorescence for staining vimentin and α-SMA. (C) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in CFs. (D) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P

Figure 5. Exosome-lncRNA ZFAS1 promoted fibrosis in ex-vivo. (A) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (B) The represented image of immunofluorescence for staining vimentin and α-SMA. (C) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in CFs. (D) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P<0.05.,**P <0.01 vs. sham-CFs, #P <0.05, ##P <0.01 vs. CKD-CFs.