Figure 1. Landscape of mutation profiles in involved hepatocellular carcinoma tissue samples. (A) Mutation information of top 20 genes in each sample. Different colors and notes at the bottom represented types of mutations. (B) Overall distribution of the six different base substitution mutation frequency (above) and conversion ratio in each sample (below). (C) Tumor mutational burden ranking of HCC among all tumors in the Cancer Genome Atlas. (D) Co-occurrence associations across top 25 mutated genes. (E) Summary of the mutation information in all HCC tissue. TMB, tumor mutational burden; SNP, single nucleotide polymorphism; SNV, single nucleotide variants. HCC, hepatocellular carcinoma.