Research Paper Volume 13, Issue 6 pp 8563—8587

A novel panel based on immune infiltration and tumor mutational burden for prognostic prediction in hepatocellular carcinoma

Infiltrating immune cells between different TMB groups and the effect on overall survival. (A) 24 types of infiltrating cells estimated by ImmuneCellAI. Different colors represent different types of immune cells, and the column length has been normalized by percentage. (B) 6 kinds of immune cells with significant infiltration in different TMB groups, and 3 others may affect the survival and prognosis of patients. (C) Kaplan–Meier survival analysis identified 4 types of immune cells that may affect the survival status. MAIT, Mucosal associated invariant T cells; Tc, cytotoxic T cells; Tex, exhausted T cells; Tr1, type 1 regulatory cells; nTreg, Natural regulatory T cells; iTreg, Induced regulatory T cells; Th1, Type 1 T helper cells; Th2, Type 2 T helper cells; Th17, Type 17 T helper cells; Tfh, Follicular helper T cells; Tcm, Central memory T cells; Tem, Effector memory T cells; NKT, Natural killer T cells; MAIT, Mucosal-associated invariant T cells; DC, Dendritic cells; Tgd, Gamma-delta T cells; TMB, tumor mutational burden; Low

Figure 3. Infiltrating immune cells between different TMB groups and the effect on overall survival. (A) 24 types of infiltrating cells estimated by ImmuneCellAI. Different colors represent different types of immune cells, and the column length has been normalized by percentage. (B) 6 kinds of immune cells with significant infiltration in different TMB groups, and 3 others may affect the survival and prognosis of patients. (C) Kaplan–Meier survival analysis identified 4 types of immune cells that may affect the survival status. MAIT, Mucosal associated invariant T cells; Tc, cytotoxic T cells; Tex, exhausted T cells; Tr1, type 1 regulatory cells; nTreg, Natural regulatory T cells; iTreg, Induced regulatory T cells; Th1, Type 1 T helper cells; Th2, Type 2 T helper cells; Th17, Type 17 T helper cells; Tfh, Follicular helper T cells; Tcm, Central memory T cells; Tem, Effector memory T cells; NKT, Natural killer T cells; MAIT, Mucosal-associated invariant T cells; DC, Dendritic cells; Tgd, Gamma-delta T cells; TMB, tumor mutational burden; Low_ IF, low Infiltrating; High_ IF, high Infiltrating.