Research Paper Volume 13, Issue 7 pp 9627—9645

Hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR-330-3p/PDCD4 axis

Hsa

Figure 9. Hsa_circ_0053063 inactivated P53 through miR-330-3p/PDCD4 axis. (A–B) Western blot assay revealed the P53 protein level in MDA-MB-231 and MDA-MB-468 cells treated with hsa_circ_0053063 siRNA. (C–D) Western blot assay revealed the P53 protein level in MDA-MB-231 and MDA-MB-468 cell lines transfected with PDCD4 siRNA. (E–G) Western blot assay revealed the protein level of P53 in MDA-MB-231 and MDA-MB-468 cell lines transfected with hsa_circ_0053063 and miR-330-3p mimics. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).