Research Paper Volume 13, Issue 6 pp 9011—9027

Functional genomics study of protein inhibitor of activated STAT1 in mouse hippocampal neuronal cells revealed by RNA sequencing

PIAS1 gene expression in four regions of human brains between normal controls and AD patients. Based on the Synapse database, the difference in PIAS1 gene expression in four regions of human brains between normal controls and AD patients was determined by using the Wilcoxon signed-rank test. (A) For the frontal cortex, there were 111 cases and 76 controls, and PIAS expression was significantly higher in AD patients, with a p value of 0.0315. (B) For the inferior frontal gyrus, there were 90 cases and 64 controls, and PIAS expression was significantly lower in AD patients, with a p value of 0.0342. (C) For the parahippocampal gyrus, there were 90 cases and 68 controls, and PIAS expression was not significantly changed, with a p value of 0.0882. (D) For the superior temporal gyrus, there were 102 cases and 65 controls, and PIAS expression was not significantly changed, with a p value of 0.527.

Figure 1. PIAS1 gene expression in four regions of human brains between normal controls and AD patients. Based on the Synapse database, the difference in PIAS1 gene expression in four regions of human brains between normal controls and AD patients was determined by using the Wilcoxon signed-rank test. (A) For the frontal cortex, there were 111 cases and 76 controls, and PIAS expression was significantly higher in AD patients, with a p value of 0.0315. (B) For the inferior frontal gyrus, there were 90 cases and 64 controls, and PIAS expression was significantly lower in AD patients, with a p value of 0.0342. (C) For the parahippocampal gyrus, there were 90 cases and 68 controls, and PIAS expression was not significantly changed, with a p value of 0.0882. (D) For the superior temporal gyrus, there were 102 cases and 65 controls, and PIAS expression was not significantly changed, with a p value of 0.527.