Research Paper Volume 13, Issue 6 pp 9043—9055

Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients

MUC4 mutation is associated with immune-related pathways. Gene set enrichment analysis was performed with the TCGA. (A) Multiple gene enrichment plot shows that a series of gene sets are enriched in the MUC4-mutant group. (B) Multiple gene enrichment plot shows that a series of gene sets are enriched in the wild-type MUC4 group. (C) Gene enrichment plots display that a series of immune-related gene sets are enriched in the MUC4-mutant group. NES, normalized enrichment score. The p-value is shown in each plot.

Figure 5. MUC4 mutation is associated with immune-related pathways. Gene set enrichment analysis was performed with the TCGA. (A) Multiple gene enrichment plot shows that a series of gene sets are enriched in the MUC4-mutant group. (B) Multiple gene enrichment plot shows that a series of gene sets are enriched in the wild-type MUC4 group. (C) Gene enrichment plots display that a series of immune-related gene sets are enriched in the MUC4-mutant group. NES, normalized enrichment score. The p-value is shown in each plot.