Figure 2. Identification of differentially upregulated expressed genes. (A) Volcano plot of mRNA expression changes between KIRC samples harboring RIPK2 high- and low- expression value. The x-axis specifies the log2 fold-changes (FC) and the y-axis specifies the negative logarithm to the base 10 of the adjusted p-values. Gray vertical and horizontal dashed lines reflect the filtering criteria. Red and green dots represent genes expressed at significantly higher or lower levels, respectively. (B) Top 10 Gene ontology enrichment terms for up-regulated (top) and down-regulated (bottom) genes, respectively.