Figure 4. Immune signaling interactions and network analysis. (A) The table showed the significant signaling networks actively compared between the RIPK2 high-, and low-expression samples by using Ingenuity Pathway Analysis (IPA) database. (B) The highest-ranked immunological signal pathway network revealed by IPA. Proteins indicated in red were up-regulated in RIPK2-high KIRC samples and the intensity of red means the foldchange. The shapes are indicative of the molecular class (i.e. protein family). Lines connecting the molecules indicate molecular relationships. In detail, dashed lines indicate indirect interactions, and solid lines indicate direct interactions. The style of the arrows indicates specific molecular relationships and the directionality of the interaction (A acts on B).