Research Paper Volume 13, Issue 7 pp 10659—10671

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway

(A, B) Toluidine blue staining of semi-thin transverse sections of STZ+Vehicle and STZ+Resveratrol mice at 12 weeks after STZ injection. The percentage of abnormal fibers was quantitated (n = 3 mice per group; data are presented as means ± SEM). (C, D) Morphological assessment of axonal and myelin in sciatic nerves from STZ+Vehicle and STZ+Resveratrol mice. Representative electron micrographs from transverse ultra-thin sections of the sciatic nerves from STZ+Vehicle and STZ+Resveratrol at 12 weeks after STZ injection. (n = 3 nerves for each group, data are represented as the mean ± SEM).

Figure 2. (A, B) Toluidine blue staining of semi-thin transverse sections of STZ+Vehicle and STZ+Resveratrol mice at 12 weeks after STZ injection. The percentage of abnormal fibers was quantitated (n = 3 mice per group; data are presented as means ± SEM). (C, D) Morphological assessment of axonal and myelin in sciatic nerves from STZ+Vehicle and STZ+Resveratrol mice. Representative electron micrographs from transverse ultra-thin sections of the sciatic nerves from STZ+Vehicle and STZ+Resveratrol at 12 weeks after STZ injection. (n = 3 nerves for each group, data are represented as the mean ± SEM).