Research Paper Volume 13, Issue 7 pp 10659—10671

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway

(A, B) Quantification by Western blot analysis showed that the expression of Nrf2 increased in STZ+Resveratrol mice at 12 weeks after STZ injection, compared with the never from STZ+Vehicle mice (n = 3 nerves for each group, data are represented as the mean ± SEM). (C, D) Immunofluorescence in longitudinal sections of STZ+Vehicle and STZ+Resveratrol sciatic nerves for Nrf2 (green) at 12 weeks after STZ injection. Nrf2 and MBP was increased in STZ+Resveratrol. (n = 3 nerves for each group, data are represented as the mean ± SEM).

Figure 3. (A, B) Quantification by Western blot analysis showed that the expression of Nrf2 increased in STZ+Resveratrol mice at 12 weeks after STZ injection, compared with the never from STZ+Vehicle mice (n = 3 nerves for each group, data are represented as the mean ± SEM). (C, D) Immunofluorescence in longitudinal sections of STZ+Vehicle and STZ+Resveratrol sciatic nerves for Nrf2 (green) at 12 weeks after STZ injection. Nrf2 and MBP was increased in STZ+Resveratrol. (n = 3 nerves for each group, data are represented as the mean ± SEM).