Research Paper Volume 13, Issue 7 pp 10659—10671

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway

(A, B) Quantification by Western blot analysis showed that Nrf2 decreased in the Nrf2-/-+STZ+Vehicle and Nrf2-/-+STZ+Resveratrol nerve, compared with WT+STZ+Resveratrol mice at 12 weeks after STZ injection (n = 3 nerves for each group, each nerve was repeated 3 times, data are represented as the mean ± SEM). (C, D) Mechanical nociceptive thresholds: ordinates represent the filament weight (0.1g) in which the animal responds in of presentations. Thermal nociceptive threshold: the axis of ordinates represents the time (seconds) the animal takes to withdraw its paw. (2 weeks after STZ induction, mice were treated with Resveratrol or Vehicle (DMSO), n = 10 mice for each group, data are represented as the mean ± SEM).

Figure 7. (A, B) Quantification by Western blot analysis showed that Nrf2 decreased in the Nrf2-/-+STZ+Vehicle and Nrf2-/-+STZ+Resveratrol nerve, compared with WT+STZ+Resveratrol mice at 12 weeks after STZ injection (n = 3 nerves for each group, each nerve was repeated 3 times, data are represented as the mean ± SEM). (C, D) Mechanical nociceptive thresholds: ordinates represent the filament weight (0.1g) in which the animal responds in of presentations. Thermal nociceptive threshold: the axis of ordinates represents the time (seconds) the animal takes to withdraw its paw. (2 weeks after STZ induction, mice were treated with Resveratrol or Vehicle (DMSO), n = 10 mice for each group, data are represented as the mean ± SEM).