Research Paper Volume 13, Issue 8 pp 11491—11506

Comprehensive analysis of ferritin subunits expression and positive correlations with tumor-associated macrophages and T regulatory cells infiltration in most solid tumors

Correlations between FTL and FTH1 expressions and immune cell infiltration determined using TIMER and TIMINER analyses. (A) TIMER analysis of the association between FTL expression and B cells, CD4+ T cells, CD8+ T cells, dendritic cells, TAMs and neutrophils in 31 solid tumors. (B) TIMINER analysis of the positive association between FTL expression and 28 immune cell subtypes, of which the most 3 were gamma delta T cells (29/32, 90.6%), Tregs (28/32, 87.5%), and TAMs (28/32, 87.5%). (C) TIMER analysis of the association between FTH1 expression and B cells, CD4+ T cells, CD8+ T cells, dendritic cells, TAMs and neutrophils in 31 solid tumors. (D) TIMINER analysis of the positive association between FTH1 expression and 28 immune cell subtypes, of which the most 3 were Tregs (25/32, 78.1%), TAMs (24/32, 75.0%), and activated dendritic cells (24/32, 75.0%).

Figure 6. Correlations between FTL and FTH1 expressions and immune cell infiltration determined using TIMER and TIMINER analyses. (A) TIMER analysis of the association between FTL expression and B cells, CD4+ T cells, CD8+ T cells, dendritic cells, TAMs and neutrophils in 31 solid tumors. (B) TIMINER analysis of the positive association between FTL expression and 28 immune cell subtypes, of which the most 3 were gamma delta T cells (29/32, 90.6%), Tregs (28/32, 87.5%), and TAMs (28/32, 87.5%). (C) TIMER analysis of the association between FTH1 expression and B cells, CD4+ T cells, CD8+ T cells, dendritic cells, TAMs and neutrophils in 31 solid tumors. (D) TIMINER analysis of the positive association between FTH1 expression and 28 immune cell subtypes, of which the most 3 were Tregs (25/32, 78.1%), TAMs (24/32, 75.0%), and activated dendritic cells (24/32, 75.0%).