Research Paper Volume 13, Issue 8 pp 12058—12066

Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity

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Figure 4. circ_0007841 is the ceRNA for miR-151-3p. (A) Predicted targets of circ_0007841 by circinteractome. (B) Luciferase reporter assay was performed to validate the interaction between circ_0007841 and predicted targets. (C) Construction of wild-type (WT) and mutant (MUT) reporter vector. (D) Luciferase reporter assay using constructed luciferase reporters. (E) qRT-PCR analysis of miR-151-3p expression after circ_0007841 silencing. (F) qRT-PCR analysis of miR-151-3p expression after circ_0007841 overexpression. (G) Expression correlation between circ_0007841 and miR-151-3p in OC tissues. *P<0.05 by Student’s t-test.