Research Paper Volume 13, Issue 7 pp 9277—9329

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Blood and cortex biomarkers showing opposite profiles in APOE2 and APOE4 strata. (A) Meta-analysis logFCs from case-control DE analysis in blood and cortex (APOE2 and APOE4 strata); (B) average expression of genes downregulated in APOE2 and upregulated in APOE4 cases by normal tissue (GTEx repository); (C) average expression of genes upregulated in APOE2 and downregulated in APOE4 cases by normal tissue (GTEx repository).

Figure 5. Blood and cortex biomarkers showing opposite profiles in APOE2 and APOE4 strata. (A) Meta-analysis logFCs from case-control DE analysis in blood and cortex (APOE2 and APOE4 strata); (B) average expression of genes downregulated in APOE2 and upregulated in APOE4 cases by normal tissue (GTEx repository); (C) average expression of genes upregulated in APOE2 and downregulated in APOE4 cases by normal tissue (GTEx repository).