Research Paper Volume 13, Issue 7 pp 9277—9329

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Cortex snRNAseq data from the ROSMAP study. (A) Cell clustering labelled by reported cell type; (B) APOE expression across cell types; (C) violin plot for APOE expression by cell type; (D) UMAP plot for average expression of cortex RRA APOE2 candidates by total gene expression; (E) UMAP plot for average expression of cortex RRA APOE3 candidates by total gene expression; (F) UMAP plot for average expression of cortex RRA APOE4 candidates by total gene expression; (G) UMAP plot for average expression of blood/cortex biomarkers by total gene expression; (H) expression by cell type of the seven genes in common in all the RRA analyses; (I) APOE expression by cell type and case status.

Figure 6. Cortex snRNAseq data from the ROSMAP study. (A) Cell clustering labelled by reported cell type; (B) APOE expression across cell types; (C) violin plot for APOE expression by cell type; (D) UMAP plot for average expression of cortex RRA APOE2 candidates by total gene expression; (E) UMAP plot for average expression of cortex RRA APOE3 candidates by total gene expression; (F) UMAP plot for average expression of cortex RRA APOE4 candidates by total gene expression; (G) UMAP plot for average expression of blood/cortex biomarkers by total gene expression; (H) expression by cell type of the seven genes in common in all the RRA analyses; (I) APOE expression by cell type and case status.