Research Paper Volume 13, Issue 13 pp 17155—17176

Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis

Expressions of the EMS-miR-758-3p-WTAP axis in human EC cells predict disease progression-free survival and overall survival. (A, C, E) Kaplan-Meier analysis of disease progression-free survival in patients with variable EMS (A), miR-758-3p (C), WTAP (E) expressions. (B, D, F) Kaplan-Meier analysis of overall survival in patients with variable EMS (B), miR-758-3p (D), WTAP (F) expressions. Based on the median value of target expression levels in tumors, these patients were categorized into expression-high and expression-low groups with 20 cases in each group. n=20 for each group. (G–I) The correlations between transcript expression levels of EMS and miR-758-3p (G), miR-758-3p and WTAP (H), EMA and WTAP (I) in primary human esophageal cancer tissues were analyzed.

Figure 5. Expressions of the EMS-miR-758-3p-WTAP axis in human EC cells predict disease progression-free survival and overall survival. (A, C, E) Kaplan-Meier analysis of disease progression-free survival in patients with variable EMS (A), miR-758-3p (C), WTAP (E) expressions. (B, D, F) Kaplan-Meier analysis of overall survival in patients with variable EMS (B), miR-758-3p (D), WTAP (F) expressions. Based on the median value of target expression levels in tumors, these patients were categorized into expression-high and expression-low groups with 20 cases in each group. n=20 for each group. (GI) The correlations between transcript expression levels of EMS and miR-758-3p (G), miR-758-3p and WTAP (H), EMA and WTAP (I) in primary human esophageal cancer tissues were analyzed.