Research Paper Volume 13, Issue 12 pp 16105—16123

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway

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Figure 1.

Effects of melatonin on cerebral infarct volume, neurological function, and brain water content in diabetic mice with CIR injury. (A) TTC staining of brain sections taken from diabetic mice with CIR injury. (B, C, D) Effects of melatonin at different concentrations on the infarct volume, neurological score, and brain water content in diabetic mice with CIR injury. Data were presented as the mean ± SEM (n = 6). &p < 0.05 vs. sham group; #p < 0.05 vs. vehicle group; *p < 0.05 vs. melatonin (5 mg/kg).