Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng; Meiling Huang; Cuicui Liu; Jiming Wang; Weihua Ren; Shaomin Cui; Jianhua Gu; Jinlan Xie; Bin Ma; Guangzhu Yang; Shuncheng He

doi:doi:10.18632/aging.203138

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Withdrawal Notice

This paper was originally published in Aging Advance Online Publications on June 27, 2021.

In compliance with Aging's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Aging internal or any external indexes or archives.

WITHDRAWN: Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Figure 6. Levobupivacaine inhibits NSCLC progression by targeting p53. (A–D) The A549 and A427 cells were treated with levobupivacaine, or co-treated with levobupivacaine and p53 shRNA. (A and B) The cell viability was measured by MTT assays in the cells. (C and D) The cell apoptosis was measure by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: ^**P < 0.01.