Research Paper Volume 13, Issue 12 pp 16198—16218

A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma

Selection of differentially expressed and survival-associated AGs based on TCGA datasets. (A) Heatmap of all genes with significant differences between lower-grade glioma (LGG) and glioblastoma (GBM) samples. (C) Volcano plot of all genes based on TCGA datasets, light blue represented downregulated of genes, and pink represented upregulated of genes. (B) Differentially expressed AGs are showed in heatmap between LGG and GBM samples. (D) Volcano plot of the four selected differentially expressed AGs, light blue represented downregulated of AGs, and pink represented upregulated of AGs. (E) Forest plot of the four differentially expressed AGs. (F) Genetic changes of the four survival-associated AGs.

Figure 1. Selection of differentially expressed and survival-associated AGs based on TCGA datasets. (A) Heatmap of all genes with significant differences between lower-grade glioma (LGG) and glioblastoma (GBM) samples. (C) Volcano plot of all genes based on TCGA datasets, light blue represented downregulated of genes, and pink represented upregulated of genes. (B) Differentially expressed AGs are showed in heatmap between LGG and GBM samples. (D) Volcano plot of the four selected differentially expressed AGs, light blue represented downregulated of AGs, and pink represented upregulated of AGs. (E) Forest plot of the four differentially expressed AGs. (F) Genetic changes of the four survival-associated AGs.