Research Paper Volume 13, Issue 12 pp 16229—16247

Testosterone ameliorates age-related brain mitochondrial dysfunction

TP supplementation activates PINK1/Parkin pathway in the SN and HIPP of aged male rats. (A) Representative western blots of PINK1, Parkin, and P62 expression in the SN. (B–D) Quantification of PINK1, Parkin, and P62 of protein expression in the SN (normalized to β-actin). (E) Representative western blots of PINK1, Parkin, and P62 expression in the HIPP. (F–H) Quantification of PINK1, Parkin, and P62 protein levels in the HIPP (normalized to β-actin). Data are expressed as the mean ± S.D. (n = 5/group). *P **P

Figure 11. TP supplementation activates PINK1/Parkin pathway in the SN and HIPP of aged male rats. (A) Representative western blots of PINK1, Parkin, and P62 expression in the SN. (BD) Quantification of PINK1, Parkin, and P62 of protein expression in the SN (normalized to β-actin). (E) Representative western blots of PINK1, Parkin, and P62 expression in the HIPP. (FH) Quantification of PINK1, Parkin, and P62 protein levels in the HIPP (normalized to β-actin). Data are expressed as the mean ± S.D. (n = 5/group). *P < 0.05, **P < 0.01 (Bonferroni test).