Research Paper Advance Articles

Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer

LncRNA AFAP1-AS1 regulated chemo-sensitivity and activity of triple-negative breast cancer (TNBC) cell lines. (A) LncRNA AFAP1-AS1 expression was up-regulated in TNBC cell lines (i.e. MDA-MB-231 and BT-549) as compared with normal breast epithelial cell line (i.e. MCF-10A). *: PB) LncRNA AFAP1-AS1 expression was decreased in MDA-MB-231 and BT-549 cell lines after transfection of si-lncRNA AFAP1-AS1. *: PC–F) Sensitivity of MDA-MB-231 and BT-549 cell lines responding to 5-Fu (C), adriamycin (D), paclitaxel (E) and cisplatin (F) was enhanced after transfection of si-lncRNA AFAP1-AS1. *: PG–I) Proliferation (G), migration (H) and invasion (I) of MDA-MB-231 and BT-549 cell lines were assessed after silencing of lncRNA AFAP1-AS1. *: P

Figure 1. LncRNA AFAP1-AS1 regulated chemo-sensitivity and activity of triple-negative breast cancer (TNBC) cell lines. (A) LncRNA AFAP1-AS1 expression was up-regulated in TNBC cell lines (i.e. MDA-MB-231 and BT-549) as compared with normal breast epithelial cell line (i.e. MCF-10A). *: P<0.05. (B) LncRNA AFAP1-AS1 expression was decreased in MDA-MB-231 and BT-549 cell lines after transfection of si-lncRNA AFAP1-AS1. *: P<0.05. (CF) Sensitivity of MDA-MB-231 and BT-549 cell lines responding to 5-Fu (C), adriamycin (D), paclitaxel (E) and cisplatin (F) was enhanced after transfection of si-lncRNA AFAP1-AS1. *: P<0.05. (GI) Proliferation (G), migration (H) and invasion (I) of MDA-MB-231 and BT-549 cell lines were assessed after silencing of lncRNA AFAP1-AS1. *: P<0.05.