Research Paper Volume 13, Issue 12 pp 16287—16315

Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer

The 2D and 3D structures of five top-scoring small-molecule drugs. (A) Top five compounds acting on the RNA-binding domain of METTL14. (B–F) 2D and 3D mapping of the binding interaction between the top five compounds (Z1791109186, Z1445387105, Z89321655, HY-N0055, and HY-102053) and METTL14. (G) The five preferred compounds targeting the m6A-binding domain of the YTHDC1 protein. (H–L) 2D and 3D mapping of the binding between the top five compounds (Z1246434517, Z2283664368, Z1455079275, HY-N0343, and HY-B0069) and YTHDC1.

Figure 10. The 2D and 3D structures of five top-scoring small-molecule drugs. (A) Top five compounds acting on the RNA-binding domain of METTL14. (BF) 2D and 3D mapping of the binding interaction between the top five compounds (Z1791109186, Z1445387105, Z89321655, HY-N0055, and HY-102053) and METTL14. (G) The five preferred compounds targeting the m6A-binding domain of the YTHDC1 protein. (HL) 2D and 3D mapping of the binding between the top five compounds (Z1246434517, Z2283664368, Z1455079275, HY-N0343, and HY-B0069) and YTHDC1.