Research Paper Volume 13, Issue 12 pp 16287—16315

Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer

Correlation between immune infiltration and the expression, mutation, SCNA status, and outcome module of METTL14. (A) Heatmap depicting the correlation of METTL14 expression with six tumor-infiltrating immune cell types (CD4+ T cells, CD8+ T cells, Treg, B cells, neutrophils, macrophages, and NK cells) and the immune infiltration level in diverse cancer types. Spearman’s correlation was used for this analysis. (B) Violin plots to visualize the effect of METTL14 gene mutations on immune cell infiltration and different infiltrating immune cell types in endometrial cancer. (C) Violin plots visualize the effect of METTL14 SCNA, including ‘deep deletion’, ‘arm-level deletion’, ‘diploid/normal’, ‘arm-level gain’, and ‘high amplification’, on immune cell infiltration and different immune cell types in endometrial cancer, as determined by GISTIC2.0. (D) Outcome module showing the clinical stage relevance of tumor immune subsets as well as the hazard ratio and P-value for the Cox model. The log-rank P-value for the KM curve is shown on the KM curve plot.

Figure 4. Correlation between immune infiltration and the expression, mutation, SCNA status, and outcome module of METTL14. (A) Heatmap depicting the correlation of METTL14 expression with six tumor-infiltrating immune cell types (CD4+ T cells, CD8+ T cells, Treg, B cells, neutrophils, macrophages, and NK cells) and the immune infiltration level in diverse cancer types. Spearman’s correlation was used for this analysis. (B) Violin plots to visualize the effect of METTL14 gene mutations on immune cell infiltration and different infiltrating immune cell types in endometrial cancer. (C) Violin plots visualize the effect of METTL14 SCNA, including ‘deep deletion’, ‘arm-level deletion’, ‘diploid/normal’, ‘arm-level gain’, and ‘high amplification’, on immune cell infiltration and different immune cell types in endometrial cancer, as determined by GISTIC2.0. (D) Outcome module showing the clinical stage relevance of tumor immune subsets as well as the hazard ratio and P-value for the Cox model. The log-rank P-value for the KM curve is shown on the KM curve plot.