Research Paper Volume 13, Issue 12 pp 16367—16380

High S100A9+ cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection

Tumor-infiltrating immune cells associated with S100A9 expression in HCC. (A) Differential infiltration of immune cells based on S100A9 expression in groups from the TCGA-LIHC cohort. The proportions of 22 immune infiltrates in tumor (n = 49) and nontumor tissue (n = 7) were estimated using the CIBERSORT algorithm. (B–E) Prognostic value of M0, M1, M2 and total (M0 + M1 + M2) macrophage densities in HCC (n = 49). (F) The densities of S100A9+ cells and CD15+ neutrophils and CD68+ macrophages were analyzed using Pearson correlation analysis (n = 382). ***P

Figure 4. Tumor-infiltrating immune cells associated with S100A9 expression in HCC. (A) Differential infiltration of immune cells based on S100A9 expression in groups from the TCGA-LIHC cohort. The proportions of 22 immune infiltrates in tumor (n = 49) and nontumor tissue (n = 7) were estimated using the CIBERSORT algorithm. (BE) Prognostic value of M0, M1, M2 and total (M0 + M1 + M2) macrophage densities in HCC (n = 49). (F) The densities of S100A9+ cells and CD15+ neutrophils and CD68+ macrophages were analyzed using Pearson correlation analysis (n = 382). ***P < 0.001.