Research Paper Volume 13, Issue 13 pp 17202—17210

Zhoushi Qiling decoction induces apoptosis of human prostate cancer cells via miR-143/Bcl-2 axis

Zhoushi Qiling decoction modulates the expression of miR-143 in DU145 human prostate cancer cells and patient serum samples. (A) Relative expression levels of miRNAs in DU145 were checked by microarray after 24 hours of treatment with 50 mg/mL ZQD. (B) miR-143 expression levels in DU145 cells were analyzed by qRT-PCR. Data were expressed as mean ± SD from three independent experiments with triple replicates per experiment. ** p C) miR-143 expression levels in patient serum samples of ADT (n=68) and ADT+ZQD (n=65) groups were analyzed by qRT-PCR. Data were expressed as mean ± SD. * p &p

Figure 3. Zhoushi Qiling decoction modulates the expression of miR-143 in DU145 human prostate cancer cells and patient serum samples. (A) Relative expression levels of miRNAs in DU145 were checked by microarray after 24 hours of treatment with 50 mg/mL ZQD. (B) miR-143 expression levels in DU145 cells were analyzed by qRT-PCR. Data were expressed as mean ± SD from three independent experiments with triple replicates per experiment. ** p < 0.01 compared with control group. (C) miR-143 expression levels in patient serum samples of ADT (n=68) and ADT+ZQD (n=65) groups were analyzed by qRT-PCR. Data were expressed as mean ± SD. * p < 0.05 compared with post-ADT group. &p < 0.05 compared with pre-ADT+ZQD group.