Research Paper Volume 13, Issue 12 pp 16500—16512

Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer

circKIF4A is upregulated in papillary thyroid cancer with circular characteristics. (A) circKIF4A expression in adjacent normal tissues and papillary thyroid cancer. (B) The relative expression of circKIF4A in cell lines. (C) RNase R assay examined the circular structure of circKIF4A in TPC-1 cell line. (D) Circular transcripts of KIF4A (circKIF4A) was more stable than its linear mRNA transcripts determined by actinomycin D treated assay.

Figure 1. circKIF4A is upregulated in papillary thyroid cancer with circular characteristics. (A) circKIF4A expression in adjacent normal tissues and papillary thyroid cancer. (B) The relative expression of circKIF4A in cell lines. (C) RNase R assay examined the circular structure of circKIF4A in TPC-1 cell line. (D) Circular transcripts of KIF4A (circKIF4A) was more stable than its linear mRNA transcripts determined by actinomycin D treated assay.