Research Paper Volume 13, Issue 12 pp 16600—16619

Development and validation of a risk prediction model and nomogram for colon adenocarcinoma based on methylation-driven genes

Validation and development of risk prediction model in colon adenocarcinoma (COAD) patients. (A) Risk score distribution in COAD patients, survival status of COAD patients, and expression heatmap of four methylation-driven genes (MDGs) in a Cancer Genome Atlas (TCGA) training cohort. (B) The K-M curve of overall survival (OS) for COAD patients between two different groups in our TCGA training cohort. (C) Time-dependent ROC curves at 1 year, 2 years, and 5 years in the TCGA training cohort. (D) Risk score distribution of COAD patients, survival status of COAD patients, and expression heatmap of four MDGs in a validation cohort. (E) The K-M curve of OS for COAD patients between two different groups in a validation cohort. (F) Time-dependent ROC curves at 1 year, 2 years, and 5 years in a validation cohort.

Figure 3. Validation and development of risk prediction model in colon adenocarcinoma (COAD) patients. (A) Risk score distribution in COAD patients, survival status of COAD patients, and expression heatmap of four methylation-driven genes (MDGs) in a Cancer Genome Atlas (TCGA) training cohort. (B) The K-M curve of overall survival (OS) for COAD patients between two different groups in our TCGA training cohort. (C) Time-dependent ROC curves at 1 year, 2 years, and 5 years in the TCGA training cohort. (D) Risk score distribution of COAD patients, survival status of COAD patients, and expression heatmap of four MDGs in a validation cohort. (E) The K-M curve of OS for COAD patients between two different groups in a validation cohort. (F) Time-dependent ROC curves at 1 year, 2 years, and 5 years in a validation cohort.