Research Paper Volume 13, Issue 13 pp 17901—17913

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

The expression of E-cadherin, Bax, Caspase3, and CD31 were up-regulated, and p-STAT3, N-cadherin, Vimentin, Bcl-2, Ki67, Slug were downregulated by CQ treatment in OS cells. (A) Representative pictures from tumor cell western blot assay. (B) The graph is the quantified data of the western blot, and β-actin was used as a load control (**p ***p n = 3). The data were expressed as the mean ± SD.

Figure 4. The expression of E-cadherin, Bax, Caspase3, and CD31 were up-regulated, and p-STAT3, N-cadherin, Vimentin, Bcl-2, Ki67, Slug were downregulated by CQ treatment in OS cells. (A) Representative pictures from tumor cell western blot assay. (B) The graph is the quantified data of the western blot, and β-actin was used as a load control (**p < 0.01; ***p < 0.001 n = 3). The data were expressed as the mean ± SD.