Research Paper Volume 13, Issue 13 pp 17227—17236

miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

Lower levels of miR-let-7c-5p and miR-149-5p expression in OA and RA patients compared with normal controls. (A) Open-source software (miRWalk, miRanda, and TargetScan) sought to identify miRNAs that could possibly interfere with IL-1β, IL-6 and TNF-α transcription. (B, C) Levels of miR-let-7c-5p and miR-149-5p expression in normal controls (n=5), OA (n=3) and RA (n=12) patients were examined by qPCR.

Figure 2. Lower levels of miR-let-7c-5p and miR-149-5p expression in OA and RA patients compared with normal controls. (A) Open-source software (miRWalk, miRanda, and TargetScan) sought to identify miRNAs that could possibly interfere with IL-1β, IL-6 and TNF-α transcription. (B, C) Levels of miR-let-7c-5p and miR-149-5p expression in normal controls (n=5), OA (n=3) and RA (n=12) patients were examined by qPCR.