Research Paper Volume 13, Issue 13 pp 17227—17236

miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

Schematic diagram summarizes the effects of miR-let-7c-5p and miR-149-5p in OA ad RA. Treatment of OASFs and RASFs with anti-inflammatory agents upregulates levels of miR-let-7c-5p and miR-149-5p expression, leading to decreases in the expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α). Thus, enhancing miR-let-7c-5p and miR-149-5p expression may be a novel therapeutic avenue for halting the progression of OA and RA disease.

Figure 6. Schematic diagram summarizes the effects of miR-let-7c-5p and miR-149-5p in OA ad RA. Treatment of OASFs and RASFs with anti-inflammatory agents upregulates levels of miR-let-7c-5p and miR-149-5p expression, leading to decreases in the expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α). Thus, enhancing miR-let-7c-5p and miR-149-5p expression may be a novel therapeutic avenue for halting the progression of OA and RA disease.